Abstract: Rivaroxaban is a new type of oral anticoagulant, which has the advantages of definite curative effect, good safety and convenient use, so it is often used in the prevention and treatment of venous thromboembolic diseases and stroke prevention of non valvular atrial fibrillation. Due to the concentration of rivaroxaban in patients, it will affect the inhibition of coagulation factor Xa, which leads to individual differences in the clinical response of patients and affects the final treatment effect. In order to use rivaroxaban more reasonably, it is necessary to monitor the concentration of rivaroxaban in human blood or urine. For the clinical needs, based on the advantages of far-infrared fingerprint spectrum and Raman characteristic spectrum in effective identification and quantitative analysis of substances, Fourier transform infrared spectrometer and laser confocal Raman spectroscopy system were used to identify and quantitatively detect rivaroxaban in liquid state. In this paper, the change of far-infrared absorption spectrum of rivaroxaban with its concentration was detected by Fourier transform infrared spectrometer, and then the change of Raman spectrum of rivaroxaban with its concentration was detected by laser confocal Raman spectroscopy system. Finally, the accuracy of far-infrared spectroscopy method and Raman method was compared. After comparison, it is proved that the accuracy of far-infrared detection is 2 times higher than that of Raman spectrum detection. These results are of great significance for the use of rivaroxaban in clinical medicine.