Abstract: As the rapid development of high-power TEA CO2 laser technology and its extensive application on industrial production, scientific research, aeronautics and astronautics and other fields, higher performance demand on control system for high-power TEA CO2 laser was put forward. A control system based on Digital Signal Processor(DSP) was designed for the high-power TEA CO2 laser, and the core module was introduced on hardware and software in detail. To overcome the severe electromagnetic interference generated during the working process of laser, shielding enclosure, power filter, safety ground, digital filter, storage and recovery of critical data, resisting reset interference and other designs were taken measure on the control system. After long term run-time test on the high-power TEA CO2 laser, the control system works stably and firmly, controlling and responding quickly, meanwhile satisfying the design request of resisting strong electromagnetic interference, with good application and popularization value.