Abstract: The transverse mode and transmission properties in frequency region of 1-100 GHz of a microstrip transmission line model based on nematic liquid crystal (LC) were studied. The influences brought by the distribution of dielectric anisotropy of liquid crystal on the solution and S-parameter of microstrip line were researched through the finite element method accurately and comprehensively, as well as the influences of the bias voltage. Simulation results indicate that the distribution property reduce the echo loss of microstrip line, which is obtained in consideration of the distribution of dielectric anisotropy of liquid. Besides, the S-parameter changes continuously since the voltage between the strip and the gound gradually increases while the resonant frequency moves the same way. Moreover, this accurate method can amend the motion of resonant frequency by 2.4 GHz, compared with the results obtained by those methods in the past. This paper provides a theory basis for researches in the field of LC microwave devices.