Abstract: Highly integrated TDI CCD focal plane system was proposed, the thick-film integrated module of TDI CCD driving unit is applied successfully in the domestic. The research was finished on highly integrated high-speed and multi-spectral TDI CCD focal plane system, including 16 channel CCD output signals and pixel read-out frequency of 20 MHz. The use of dual-channel CCD signal processing analog front end, thick-film integrated drive unit module, high-speed image data transmission LVDS interface and mechanical, electrical, thermal integrated and simulated design approach greatly increases the integration of TDI CCD focal plane system and reduces the complexity of system interconnection. The system includes four image data transmission interfaces, each transmission capacity is 1.6 Gbps to 2.5 Gbps. It is up to 10 Gbps total of the image data bandwidth, ensuring high data rates and improving anti-interference performance of data transmission. The system design and multi-spectral TDI CCD detector working principle was described. As the key technologies, mechanical and electrical integrated design, thick-film integrated technology of drive unit and high-speed serial transmission bus technology were analyzed. The system was tested by using TDI CCD transfer function test chip, average value of modulation transfer function is 0.511 in the total focal plane system.