Abstract: The experimental phenomena and laws of the supercontinuum laser irradiating the visible light CMOS image sensor were studied. Some typical interference phenomenon was observed with the incident laser power increasing, like pixels saturation, partial saturation, local supersaturation and full screen saturation of the output image with CMOS sensor. A comparison of the similarities and differences between the 1 060 nm mode-locked fiber laser and supercontinuum on affecting the quality of CMOS imagers was described from three aspects such as effective jamming area, image correlation and image variance. It is found that the response characteristic of CMOS image sensor, the spectrum characteristic of the laser and the dispersion of the imaging optical system lead to the difference of interference effects.