Abstract: The high-power Q-switched pulse fiber laser was constructed. The high power pulse fiber laser was amplified to 101.4 W with the MOPA structure, with the output central wavelength of 1 064.52 nm. The repetition frequency of the pulse was 100 kHz with pulse width of 138.4 ns. The optical to optical conversion efficiency of master amplifier was about 80%. The laser stripping experiment system based on the high-power fiber pulse laser was constructed and it was applied in stripping the surface varnish layer of high-speed rail carriage. The effects of energy density and galvanometer scanning speed on the stripping of varnish were studied. The stripping threshold of the varnish layer was 19 108 mJ/cm2, stripping thickness was about 22 m. The damaged threshould was 34 392 mJ/cm2, the stripping efficiency could be up to 1 m2/h.