Abstract: Fatigue driving is the main cause or reason for traffic accidents, which has a huge influence on social safety. Considering the fact that light change and glasses could significantly increase the difficulty to monitor human eyes, fatigue detection was still an unsolved problem. A new driver fatigue method based on morphology infrared features and deep learning were proposed. Using 850 nm infrared light source, the facial image was obtained. Human faces and landmarks which indicated the area of eyes were located by Convolution Neural Network (CNN) with morphology features in infrared image. In the next step, a filter module which measured head displacement was added, aiming at reducing the impact of posture change. In the following, the collected facial states were transformed into sequential data. Finally, the sequential data was passed to the Long Short Term Memory (LSTM) network to detect fatigue state by analyzing the sequential correlations. Experimental results show that the accuracy of the fatigue detection algorithm can reach 94.48% with an average detection time of 65.64 ms.