Abstract: In order to solve the output wavelength and power stability of high power semiconductor laser, high power semiconductor laser constant current driver and temperature control system were designed. Deep negative feedback circuit was used to control the laser drive current, the analog Proportional-Integral (PI) circuit and constant current driver were adopted to control the working current of Thermoelectric Cooler (TEC), the laser working temperature can be kept accurately. The design can realize the linear adjustment of output current from 0-12.5 A, and has the function of current detection, over-current protection and Transistor-Transistor Logic (TTL) modulation. The control precision of the temperature control system can achieve 0.05℃. Temperature can be adjusted continuously and can be monitored in real time. Experiment results show that the design can guarantee the output current and temperature control stably, which satisfies the requirement of high power semiconductor laser.