Abstract: Based on aerosol data measured at sea from August 2004 to December 2016, the variation of aerosol particle number concentration and particle size distribution dependent on meteorological conditions was studied. Aerosol data were measured in the offshore sea of Maoming, Guangdong as well as the Pacific Ocean and the Indian Ocean. There were two parts included in the data:(1) the particle number of atmospheric aerosol measured by the Optical Particle Counter (OPC); (2) it was measured that atmospheric temperature, relative humidity, air pressure, wind speed and other meteorological parameters by Forain Weather System etc.. The variation of particle size distribution on different meteorological conditions was analyzed, i.e. the variation of particle size distribution was simulated under different relative humidity and wind speed following by the value of theoretical analog was compared with that of actual measured. The results show that, on the one hand, it is realistic to retrieve the influence of relative humidity on particle distribution by using the model of r(RH)/r=(1-RH)-1/3.9. On the other hand, it is reasonable to utilize the model of lgN=aU+b to retrieve the effect of the wind speed on particle size distribution. There is an important guiding significance for the establishment of ocean atmospheric aerosol model.