Abstract: The laser seeker, which is the main dependent object of the missile to achieve reliable target attack, provides the position information of the target for the laser-guided weapon. During the missile flight, the missile's disturbance was coupled to the servo stabilization system of the seeker in various ways. This will affect the stability of the visual axis as well as reducing the accuracy of the seeker in locating the target. The basic structure of the seeker servo system and the basic principle of achieving the stability of the visual axis were analyzed in this paper. In order to solve the disturbance problem of the seeker, a Fuzzy Sliding Mode Control(FSMC) method was proposed. The Sliding Mode Control(SMC) has the advantage of fully adaptive to the disturbances. Besides, it was combined with fuzzy control, which can reduce chattering of SMC. In this way, the robustness of the seeker servo system was improved by FSMC, so did the isolation of the seeker. The simulation results show that compared with PID control, fuzzy sliding mode control can improve the control quality of the system and achieve better control accuracy and response speed.