Abstract: Optical scattering inherent in biological tissue prohibits optical technologies from being widely used in biomedical applications. Wavefront shaping treats optical scattering as a deterministic process, enabling the control of scattered light by point-by-point phase compensation through spatial light modulators. Among various wavefront shaping technologies, digital optical phase conjugation controls the largest number of degrees of freedom and has the fastest speed, which is suitable for biomedical applications such as live-tissue imaging, manipulation, and therapy. This paper will describe the development of digital optical phase conjugation, discuss the main technological challenges encountered, and speculate on future applications.