Abstract: In order to achieve the purpose of real-time atmosphere turbulence simulation by used liquid crystal spatial light modulator, A new computing method of liquid crystal atmospheric turbulence simulator real-time wave-front generation based on GPU has been proposed. According to the characteristics of liquid crystal turbulence simulator, which is high resolution, high precision, The Compute Unified Device Architecture was discussed in this paper. Furthermore, a wave-front generation model based on GPU was established with parallel optimization and share memory optimization. Finally, the experimental results by used CPU and GPU wave generation was given. The result shows that: the consumed time by proposed method is less than 2 ms for a Zernike polynomial with 231 wave-front values in resolution of 256256, which is two orders of magnitude less than that of CPU, fully meets the real-time wave-front generation requirements.