Abstract: In the real IR detector, the high frequency non-uniformity is mostly expressed as the column or the row stripes and the low frequency non-uniformity is mostly expressed as the patchy pattern. In real application, the scene is towards one continuous monotonous direction and has different appearances of non- uniformity. Under this consideration, a scene-based non-uniformity correction technology was proposed, it not only fitted the situation mentioned above but also was realized on the small packaged, low power consumed real-time hardware system. These problems were solved by developing a new projection estimator for the registration with a criterion, and this algorithm was immigrated into a FPGA_based hardware system. This system is fully engineered for some particular usage. The performance of the proposed technology was tested by the evaluation indexes, and it demonstrates the actual effect of correcting the non-uniformity under a monotonous motion on the system. According to the practical application, this algorithm has the advantage of the strong ability to eliminate the image degradation and fast convergence speed.