Abstract: In order to improve the cruising guidance ability of the remote anti-ship missile and to increase the effctive range, based on the objective analysis for the future sea battlefield and the features of the celestial navigation about small field of view, a celestial angle measurement based guidance way was put forward which will serve as the main method for the guidance of remote missile on it's cruise phase, gave out the system analysis for feasibility and listed the superiorities. With the new concept of guidance angle, the guidance system can be divided into three stages, namely initial parameters's binding and calculation, guidance angle's correction and terminal guidance confirmation, their respective calculation formula and related derivation were given, a specific example was used to carry out computer simulation. The simulation results show that guidance system can serve as an effective cruise guidance method, it witnesses a successive guidance angle and a permitted error, which bears important significance for the overal design of modern missile.