Abstract: With the development of information technology, space imaging has been developed toward high-definition and multi-channel direction. Real-time video compression system, based on general-purpose DSP and H.264/AVC video coding standard, due to short development cycle, high reliability, high processing speed, ease of upgrades, small size, low power consumption and high adaptability, can provide a solution for the new requirements. Therefore, it is of great importance to study real-time video encoder based on general-purpose DSP and advanced video compression technology. To meet the application needs of more and more high-definition video capture, coding and transmission, TI's new generation multi-core TMS320DM8168 chip was used for development, and the design and implementation of system was proposed, and then the H.264 video encode algorithm was realized for dual 1080p input video. The main processor of the scheme needs only a piece of DSP. Compared with the traditional video compression schemes which need multi processor, this highly integrated scheme reduces the number of parts and materials(BOM)cost, power requirements and the size of PCB, and increases the system integration.