Abstract: During the lifetime test of IR component, the component needed to remove from its vacuum chamber of lifetime test in every parameter measurement, however, the movement may destroy the IR component. To deal with this problem, an automated, multi-station vacuum system for infrared component lifetime test was presented in this paper. By use of a specially designed Dewar as the lifetime test center, it achieved the situ parameter measurement. By the vacuum calculation and computer 3D modeling, the structural of the system was designed. By use of system programmable logic controller (PLC) as the control center, it achieved real-time monitoring and failure alarm protection of the vacuum environment for the lifetime test. Finally, exhaust gas experiment is performs and the results shows that the vacuum system operates normally, and the no-load vacuum pressure is up to 3.6710-6 Pa in the case of liquid nitrogen cooling, which meet the requirement of the long-term lifetime test for space application of infrared detector assembly.