Abstract: Using high-resolution full frame area array CCD FTF5066M as aerial image sensor of the camera, its frame rate is generally not more than 1 fps, which can not meet the high frame rate applications. Firstly, the full frame area array CCDFTF5066M drive circuit was introduced in this paper, and it was also been improved. Using CCD four output amplifiers to output at the same time, the highest frame rate reached 3.4 fps. Secondly, the timing of the CCD driver, front-end processing circuit, DC bias circuit, interface circuit of the four outputs were designed. The improved driver circuit could meet the application requirements of various aerial camera. Then the full frame area array CCDFTF5066M non-uniformity was analyzed, and a non-uniform response detection system was established. Using this system, the array CCD5066M's non-uniformity between the four quadrants and each pixel was tested separately. On the basis of CCD linear responsivity, two correction algorithm was proposed to correct the non-uniformity. At last, by correcting, the four quadrants's standard deviation of response sensitivity was reduced to the original's 1/13. Through the re-shoting of the identify rate board, it can seen that the array CCD's non-uniformity has been improved obviously.