Abstract: In this paper, the Raman spectroscopy measurement system was presented, where Shell-isolated Nanoparticle Enhanced Raman Spectroscopy(SHINERS) technique was used to amplify the Raman signal. This technique used gold nanoparticles coated with a thin, uniform, fully enclosed and optically transparent shell of silica or alumina so that the gold core generated a large surface enhancement. Based on this technique, the hardware framework of this measurement system was mainly composed of double central control chips(ARM and DSP), a laser diode source, a spectrometer, a fiber probe and a nanoparticle giving device; and the software of this system can achieve the Raman spectrogram automatically. The giving device was used to spread the SHINERS particle into the samples for improving automation. The experiments were performed to detect the food added melamine and malachite green for verifying the effectiveness of SHINERS. The results show that the measurement system is of high detection sensitivity and short testing time effectively, which can be widely adopted in the rapid detection of trace substances in food safety.